Brugmans, L.J.L.

repair recombination protein nonhomologous end-joining mutation nbs 1 nonhomologou rad 54 end-joining 54−/− pathway radiation dna ligase iv sensitivity function damage rad 51 mouse dna damage es cells mre 11 defect double-strand replication chromosomal patient dna repair checkpoint mutant chk 2 phosphorylation genes dev cell biol kanaar treatment rad 54−/− mice paralog artemi brca 1 rad 51 paralogs research phase phenotype radiation sensitivity embo j van gent rad 52 dna double-strand formation brugman analysis patient sc 2 cancer rad 51 foci ligase result dsb repair inhibitor esser dna-pkc level break dsb repair pathways ficiency brca 2 ficient number lethality assay stability cycle yeast agent petrini survival ku 80 strand nature mitomycin c mechanism development