Kim, R.B.

imatinib oatp 1a rosuvastatin study variant patient slco 1a variants uptake pharmacokinetic transport transporter cancer figure imatinib transport concentration interaction expression tissue level plasma control number transfected cgp 74588 pharmacol absorption oocyte result polypeptide 7.4 blood effect 2003 c >g sample xenopus laevis oocytes value polypeptide oatp 1a oatp 1a variants drug –transporter interactions slco 1a carrier rodent oatp 1a imatinib plasma levels oatp 1a transport imatinib absorption therapeutic *** pharmacology 37 ° c cancer res imatinib pharmacokinetics ph 7.4 volume response protein association inhibitor genotype xenopu laevi anion difference report polypeptide 1 transporter consortium center ph values duodenum uptake transporter finding myeloid leukemia administration ph-dependent manner influence bioavailability 2 weeks 37 ° absence pharmacogenetic abcb 1