Middendorp, S.

b cells pre-b expression b cell development pre-b cells chain development kinase receptor btk-deficient tyrosine kinase immunol tyrosine slp -65 rearrangement -65 surface protein pre-bcr activation receptor editing 3-83 btk-deficient mice stage culture b-cell spleen function bruton number defect figure mouse bone marrow il -7 result level differentiation e 41k tumor editing activity domain marrow pre-b cell stage pro-b analysis usage absence immunity response presence background phenotype hendrik pro-b cells maturation antibody control mutation cytoplasmic marker btk mice x-linked pre-b cell compartment l chain rearrangement signal factor phosphorylation x-linked agammaglobulinemia molecule sp 3 / population locus btk /slp recombination migration tumor suppressor cycling chapter