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melanin mycetomati strain antifungal amphotericin b heart embryo agent hypoxic susceptibility lv muscle bundles antifungal agents method ketoconazole itraconazole fragment amphotericin hypoxia chick system cluster madurella mycetomatis bundle fl uconazole sudan muscle mycetoma assay figure study sensititre disease lesion marker netherland lv dilatation madurella hypoxic embryos effect grain difference microbiol hypoxic hearts voriconazole growth level analysis fl ucytosine concentration hypoxic chick embryos titin species sande sensititre system xtt assay cardiomyopathy uconazole cluster i agents chemother dilatation protein university normoxic cryptococcus neoformans mycetomatis strains neoforman binding melanised infection cardiomyocyte restriction azole fungi isoform dhn-melanin testing sequence l-dopa melanin fication van belkum