Bruggenwirth, H.T.

receptor androgen mutation protein patient binding residue ar gene skin fibroblasts androgen receptor gene expression dna-pk transcription activation hormone androgen receptor study dna ends phenotype activity presence family analysis domain dna-pkc figure position androgen insensitivity syndrome fibroblast transcription activation ligation dna binding absence assay autophosphorylation insensitivity level result reaction promoter plasmid subject individual region trapman j zinc cluster sequence brinkmann syndrome structure substrate codon kinase addition acid residues cluster factor cancer probe splice androgen insensitivity stretch ar protein endocrinol type ar dna-dependent protein kinase interaction wild-type dna substrate length intron trapman ligase dna-pkcs autophosphorylation fragment prostate dna termini substitution prostate cancer alanine residue