Goedhart, J.

protein repair ddb 2 lesion binding damage irradiation uv irradiation model dna lesions ddb 2-eyfp excision factor kinetic complex nucleotide excision repair nucleotide assembly dna repair 2-eyfp cul 4a dna damage accumulation chromatin fluorescence result 6-4 pps uv-c irradiation houtsmuller ner proteins 6-4 hoogstraten tfiih analysis repair intermediates 37° c vermeulen uv-damaged dna recognition intermediate dissociation curve concentration hoeijmaker ner factors intensity specificity affinity uv-damaged repair proteins level dna unwinding study unwinding protein complexes number state mechanism mobility erasmus university rotterdam incision dna repair intermediates 16 j /m unwound molecule ctx-m uv-induced experiment repair synthesis ligase repair factors luijsterburg repair complexes second science system ddb 2 molecules recovery degradation synthesis