Planken, M. van der

fviii patient willebrand ddavp vwd type 1 von willebrand disease disease response vwf multimers mutation factor blood group >250 type 1 erasmus univ rotterdam vwf parameters type 2 multimer fviii /vwf level von willebrand factor study value recessive ratio parameter type 2 vwd table michiel treatment missense domain blood group thromb loading dose allele prophylaxi hemate-p rotterdam vwf deficiency haematol half life times erasmu abo blood group surgery deficiency alphanate pattern downloaded cat.sagepub.com type 3 vwd defect type 1 vwd laboratory vwd patients immunate absence 12 hours vwd type 3 carrier vwf multimeric pattern missense mutation loading diagnosis multimeric bleeding minute classification triplet structure >20 haemate-p missense mutations effect gadisseur type 2 m platelet recessive type 1 thrombosis vwf levels