Ballmann, M.

patient response fibrosis sibling conductance disease f 508 tissue dizygou conmild gluconate consevere cl secretion measurement figure secretion amiloride chloride function monozygou f 508 cftr solution table study individual channel secretory isoprenaline mutation cl conductance carbachol lung function presence histamine phenotype value number fev 1perc basal group cl secretory response transport expression gluconate response epithelium cl secretory responses cf disease consevere pairs dizygous pairs basal cl conductance influence non-twin 1perc december investigation analysis transmembrane addition airway difference factor cl-free solution monozygous pairs chloride secretion cftr gene cf patients disc pairs defect range volume patient pairs f 508 homozygotes data points pdsibb ic measurements disease severity sibling pairs severity delta sweat