Moné, M.J.

repair protein model system concentration design control equation parameter lesion binding reaction receptor ligand enzyme nucleus function network biology figure analysis pathway membrane state complex process dna lesions rate equations import damage factor importin mechanism value number ficient component dna repair excision kinetic approach systems biology transport accumulation westerhoff response assembly behavior molecule signal transcriptional response plasma membrane nucleotide excision repair ner proteins parameter values nucleotide property principle cytoplasm transcription export modeling tfiih result repair intermediates intermediate recognition dissociation substrate ner factors irradiation 2010 embo transcriptional macmillan publishers specificity affinity rate equation cargo dna damage repair proteins