Parchi, P.

disease prion patient protein position mutation amyloid neuro fibrillary tangles prion protein genotype amyloid angiopathy allele brain polymorphism creutzfeldt-jakob creutzfeldt-jakob disease prion disease neuropathol prpsc cortex neuro fibrillary duration plaque alzheimer prion diseases cathepsin analysis y 226x mutation deposit codon antibody q 227x mutation accumulation month ??? angiopathy phenotype patient 2 tangle survival dementia deposition neurology fragment prp-caa blood vessels netherland prion protein gene sample distribution signi amyloid depositions examination illness residue result codon mutations prion protein amyloidoses feature control carrier neuro fibrillary lesions c 224t polymorphism ficant multicentric amyloid plaques blood homozygote patient 1 vessel study frontotemporal dementia disease duration fference staining frequency pathology number formation section