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scopus: 6506586661

Fuhler, G.M.

(Gwenny Fuhler)


myeloma expression protein phosphatase kinase pathway plasma leukemia cancer activity phosphorylation inhibitor activation patient cd 138− cells plasma cells mm cells cd 138+ cells blood treatment growth 138− analysis tyrosine flow cytometry level factor ptdin figure rpmi 8226 cells study inhibition tumor result marrow survival receptor cytometry ptp 1b disease myeloma cells cd 45 resistance malignancy 138+ stromal cd 138− apoptosi cd 38 ship 1 sample presence substrate opm 2 cells myeloid leukemia myeloid target mutation co-culture antibody addition inositol ship 2 haematological malignancies haematological mm cell lines percentage 3 ac treatment number cd 45 expression mm pc signal effect cd 138-negative cells concentration lucena speci mg 63 cells neoplastic plasma cells / biochimica




7 Most Recent Publications

Therapeutic potential of SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) and SHIP2 inhibition in cancer (Article)
Fuhler, G.M. Brook, R.H. Tom, B. Iyer, S. Gengo, E.A. Park, M.Y. Gumbleton, M. Viernes, D.R. Chisholm, J.D. Kerr, W.G.
2012-01-01
Major remodelling of the murine stem cell kinome following differentiation in the hematopoietic compartment (Article)
Hazen, A.L. Diks, S.H. Wahle, J.A. Fuhler, G.M. Peppelenbosch, M.P. Kerr, W.G.
2011-08-05
Widespread deregulation of phosphorylation-based signaling pathways in multiple myeloma cells:Opportunities for therapeutic intervention (Article)
Fuhler, G.M. Diks, S.H. Peppelenbosch, M.P. Kerr, W.G.
2011-07-01
Hedgehog signaling maintains chemoresistance in myeloid leukemic cells (Article)
Queiroz, K.C.S. Ruela-de-Sousa, R.R. Fuhler, G.M. Aberson, H.L. Ferreira, C.V. Peppelenbosch, M.P. Spek, C.A.
2010-12-02
Reversible phosphorylation in haematological malignancies: Potential role for protein tyrosine phosphatases in treatment? (Article)
Ruela-de-Sousa, R.R. Queiroz, K.C.S. Peppelenbosch, M.P. Fuhler, G.M.
2010-08-09
Bone marrow stromal cell interaction reduces Syndecan-1 expression and induces kinomic changes in myeloma cells (Article)
Fuhler, G.M. Baanstra, M. Chesik, D. Somasundaram, R. Seckinger, A. Hose, D. Peppelenbosch, M.P. Bos, N.A.
2010-07-01
Report of the European Myeloma Network on multiparametric flow cytometry in multiple myeloma and related disorders (Article)
Rawstron, A.C. Orfao, A. Kovarova, L. Lioznov, M. Mateo, G. Morilla, R. Mylin, A.K. Omedé, P. Pellat-Deceunynck, C. Andres, M.P. Petrucci, M. Ruggeri, M. Beksac, M. Rymkiewicz, G. Schmitz, A. Schreder, M. Seynaeve, C.M. Spacek, M. Tute, R.M. de Valckenborgh, E. van Weston-Bell, N. Owen, R.G. San Miguel, J-F. Bezdickova, L. Sonneveld, P. Johnsen, H.E. Brooimans, R.A. Bumbea, H. Dalva, K. Fuhler, G.M. Gratama, J-W. Hose, D.
2008-03-01