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globin locus expression deletion - globin gene region promoter stage transcription result grosveld fragment mouse control level interaction element sequence ±50 b-globin recombination liver - globin locus adult analysis - globin promoter globin genes signal figure b-globin gene clone ±50 region blood development wild-type plasmid β- globin locus effect γ- globin expression probe γ- globin genes assay regulation g-globin chromatin transcript number mutation enh /f deletion grosveld f globin locus erythroid cells vector b gene transcriptional dnasei wijgerde ⌬3⌬ g-globin gene promoter modification erythroid g gene e.coli g-globin gene hybridization study minilocu palstra wtgbmini embo j pac 148 embryo increase chromatin structure chromosome globin gene expression f elements yolk sac stage liver cells b genes
5 Most Recent Publications
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Multiple interactions between regulatory regions are required to stabilize an active chromatin hub.
(Article)
Patrinos, G.P. Krom, M. de Boer, E. de Langeveld, A. Imam, A.M.A. Strouboulis, J. Laat, W.L. de Grosveld, F.G. |
2004-06-15
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An embryonic specific repressor element located 3' to the Ay-globin gene influences transcription of the human beta globin locus in transgenic mice.
(Article)
Katsantoni, E. Krom, M. de Imam, A.M.A. Kong a San, J. Grosveld, F.G. Strouboulis, J. Anagnou, N.P. |
2004-02-01
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The role of the -50 region of the human gamma-globin gene in switching.
(Article)
Ristaldi, M.S. Drabek, D.D. Gribnau, J.H. Poddie, D. Yannoutsos, N. Cao, A. Grosveld, F.G. Imam, A.M.A. |
2001-09-17
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Modification of human beta-globin locus PAC clones by homologous recombination in Escherichia coli
(Article)
Patrinos, G.P. Krom, M. de Bottardi, S. Janssens, R.J. Katsantoni, E. Wai, A.W. Sherratt, D.J. Grosveld, F.G. Imam, A.M.A. |
2000-01-01
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Role of the duplicated CCAAT box region in γ-globin gene regulation and hereditary persistence of fetal haemoglobin.
(Article)
Ronchi, A. Berry, M. Raguz, S. Imam, A.M.A. Yannoutsos, N. Ottolenghi, S. Grosveld, F.G. Dillon, N. |
1996-01-01
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