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effect receptor release somatostatin culture octreotide binding som 230 tumor treatment patient control analog hormone secretion adenomas subtype expression study adenoma concentration incubation level inhibition acth release medium value sst 2 gh release prolactinoma sst 5 receptors lambert internalization library erasmus mc rc -160 hormone release ss analogs corticotroph gh-secreting sst 5 20 cells endocrinology van koetsveld pm adenoma cells -20 cells group tumor cells h 295 cells bromocriptine endocrinol crh-induced acth release -14 ifn -β1a tissue -160 control cells radioligand growth membrane corticotroph adenomas number downloaded metab hofland somatostatin receptors prl release mouse thymu ifnar i-tyr prl secretion -20 bim -23014 glucocorticoid cushing hormone secretion basal acth release sw 13 cells interferon ss -14
9 Most Recent Publications
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Potent inhibitory effects of type I interferons on human adrenocortical carcinoma cell growth.
(Article)
Koetsveld, P.M. van Vitale, G. Lamberts, S.W.J. Hofland, L.J. Herder, W.W. de Feelders, R.A. Wansem, K. van der Waaijers, M. Eijck, C.H.J. van Speel, E.J. Croze, E. Lely, A.J. van der |
2006-11-01
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Distinct functional properties of native somatostatin receptor subtype 5 compared with subtype 2 in the regulation of ACTH release by corticotroph tumor cells.
(Article)
Hoek, J. van der Waaijers, M. Culler, M.D. Lamberts, S.W.J. Hofland, L.J. Koetsveld, P.M. van Sprij-Mooij, D. Feelders, R.A. Schmid, H.A. Schoeffter, P. Hoyer, D. Cervia, D. Taylor, J.E. |
2005-08-01
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The multi-ligand somatostatin analogue SOM230 inhibits ACTH secretion by cultured human corticotroph adenomas via somatostatin receptor type 5.
(Article)
Hofland, L.J. Hoek, J. van der Beckers, A. Lamberts, S.W.J. Feelders, R.A. Aken, M.O. van Koetsveld, P.M. van Waaijers, M. Sprij-Mooij, D. Bruns, C. Weckbecker, G. Herder, W.W. de |
2005-04-01
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The novel somatostatin analog SOM230 is a potent inhibitor of hormone release by growth hormone- and prolactin-secreting pituitary adenomas in vitro
(Article)
Hofland, L.J. Lely, A.J. van der Weckbecker, G. Feelders, R.A. Lamberts, S.W.J. Beckers, A. Hoek, J. van der Koetsveld, P.M. van Herder, W.W. de Waaijers, M. Sprij-Mooij, D. Bruns, C. |
2004-01-01
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Age-related decrease of somatostatin receptor number in the normal human thymus
(Article)
Ferone, D. Pivonello, R. Hagen, P.M. van Waaijers, M. Zuijderwijk, J. Colao, A. Lombardi, G. Bogers, A.J.J.C. Lamberts, S.W.J. Hofland, L.J. |
2000-01-01
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Interferon-alpha-2a is a potent inhibitor of hormone secretion by cultured human pituitary adenomas
(Article)
Hofland, L.J. Herder, W.W. de Waaijers, M. Zuijderwijk, J. Uitterlinden, P. Koetsveld, P.M. van Lamberts, S.W.J. |
1999-01-01
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Dissociation between the effects of somatostatin (SS) and octapeptide SS-analogs on hormone release in a small subgroup of pituitary- and islet cell tumors
(Article)
Hofland, L.J. Herder, W.W. de Visser-Wisselaar, H.A. Uffelen, C. van Waaijers, M. Zuyderwijk, J. Uitterlinden, P. Koetsveld, P.M. van Lamberts, S.W.J. Kros, J.M. |
1997-01-01
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Internalization of the radioiodinated somatostatin analog [125I-Tyr3]octreotide by mouse and human pituitary tumor cells: increase by unlabeled octreotide
(Article)
Hofland, L.J. Koetsveld, P.M. van Waaijers, M. Zuyderwijk, J. Breeman, W.A.P. Lamberts, S.W.J. |
1995-01-01
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Relative potencies of the somatostatin analogs octreotide, BIM-23014, and RC-160 on the inhibition of hormone release by cultured human endocrine tumor cells and normal rat anterior pituitary cells
(Article)
Hofland, L.J. Koetsveld, P.M. van Waaijers, M. Zuyderwijk, J. Lamberts, S.W.J. |
1994-01-01
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