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injury brain mglur brain injury ethanol study spike cerebellar receptor culture control level purkinje effect aldolase blood flow damage blood model presence animal calcium glutamate impact death aldolase c synaptic neurosci insult purkinje cells induction 24 h post-injury recording trauma contusion amplitude tissue 2 signals signal 2 transients 15 min neuron weber current condition activation number hippocampal mglur 1 control conditions motor change transient application volume stretch reduction dendritic increase post-injury synapses image slemmer -100b result neurotrauma aldolase c sirna plasticity mglur 1–epscs pri uptake dendrite ± sem signi value mglur 1 receptors metabotropic metabotropic glutamate receptors hansel synaptic plasticity slice