Queiroz, K.C.S.

pathway cancer phosphatase leukemia protein expression tumor activity kinase resistance hh pathway activation inhibitor tyrosine lmw-ptp hedgehog lucena mutation treatment phosphorylation patient level ptp 1b cd 45 malignancy growth receptor inhibition study target k 562 cells myeloid leukemia myeloid k 562 factor figure blood development mechanism chemoresistance result overexpression haematological malignancies haematological disease proliferation signal survival therapy addition speci / biochimica medulloblastoma queiroz myeloma domain lmwptp regulation pancreatic cd 45 expression ptdin chemotherapy inositol tc-ptp substrate vincristine lymphoma characteristic function pi 3k pathway heptp basal cell carcinoma leukemia kcs queiroz apoptosi metastatic gli 1 differentiation hematopoietic hh pathway inhibitors antagonist