Vissers, C.J.

1*292 ercc 1*292 mice repair ercc 1-mutant mice ercc 1 wild-type 1-mutant mouse knockout analysis ercc 1 knockout protein liver probe mutation ercc 1-mutant mefs fragment cycle level abnormality ercc 1 gene ercc 1*292 mefs +/+ life span recombination cross-link xpa / mice p 21cip kidney defect ercc 1*292 mutation cell cycle arrest survival control fibroblast figure bamhi allele nuclei ercc 1 protein background ercc 1*292 blot analysis syndrome cross-link repair *292 senescence group clone offspring function region sensitivity replicative senescence effect vol 7 ercc 1mutant mice mcwhir ercc 1*292 allele result mice weeda 30 g dmba treatment tissue mutant addition number section growth arrest 21cip lesion phenotype c 57bl agent disruption wild-type litter-mates genomic dna repair culture