Paré, P.D.

airway fi brosis brosi disease study function patient respir children infant obstruction cf lung disease effect volume fev 1 lung disease submucosal glands airway obstruction lung function surface mucus fi brosis patients muscle airways obstruction change airways disease fef 75 clearance pediatr pulmonology tidden therapy aerosol expiratory lung volumes submucosal trial fef 25–75 boucher rc expiratory fl ow result gland secretion deposition airway surface mucociliary clearance cf patients measure treatment abnormality air flow limitation addition inhaled 25–75 pulmonol technique delivery spirometry saline evidence mucociliary control property pseudomonas aeruginosa hypertonic fev 1. fl uid recoil infection surface tension screening process gas washout ficient layer mucus layer rhdnase hypertonic saline disease process physiol