Dumoulin, J.C.M.

oocyte mutation children study mtdna singleton health ivf twins outcome mitochondrial analysis embryo ivf singletons embryo transfer transfer pregnancy sample reprod netherland strategy health problems health outcomes birth centre heteroplasmy number data collection problem cost-effectiveness hospital embryo transfer strategies level model mitochondrial dna patient result maastricht maastricht university university parent fragment collection department information point mutations det strategies twinsing study treatment dhplc analysis dhplc van heesch ivf treatment base sample pediatrics heteroplasmic bottleneck 18- year cycle development twinsing child heesch point genet birth weight woman homoplasmic complication category evers jl chinnery heteroplasmic mutations markov model perinatal change van den bosch outcome data health status 26 oocytes d-loop