Holt, D.W.

patient transplantation transplant mpa exposure exposure concentration study mycophenolate mofetil mycophenolate recipient rejection mofetil mycophenolic mycophenolic acid pharmacokinetic transplant recipients group monitoring drug monitoring liver tacrolimu target month relationship mpa auc 0 time points university therapy department dosing plasma point value oellerich m hospital nephrology trough trial randomized incidence outcome range nephrol treatment analysis method fixed-dose efficacy mpa concentrations gelder assay result mycophenolic acid exposure 12 hours dosage strategy metabolite sample roche armstrong vw hoffmann-la roche ltd van gelder t mpa tdm organ transplantation organ sampling glucuronide liver transplantation kidney tonshoff b treatment failure liver transplant recipients cyclosporine effect american society heart oellerich toxicity sampling strategy monit