Tönshoff, B.

patient transplantation transplant study mpa exposure recipient mycophenolate mofetil exposure mycophenolate concentration transplant recipients rejection mofetil adult mycophenolic pharmacokinetic mycophenolic acid drug monitoring group monitoring month therapy children paediatric tacrolimu dosing trial target efficacy liver kidney analysis university plasma sampling value nephrol cyclosporine effect relationship outcome mpa auc 0 oellerich m time points strategy hospital range organ transplantation department fixed-dose event treatment armstrong vw incidence point ec-mp result mmf dose sampling strategy metabolite organ nephrology trough population function roche randomized mpa-auc profile table method mpa concentrations gelder subgroup analysis assay graft enteric-coated mycophenolate sodium mycophenolic acid exposure 12 hours dosage