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tumour adhesion mesothelial growth tumour recurrence mesothelial cells recurrence tumour cells tumour cell adhesion trauma effect tumor factor study cytokine cancer cc 531 cells tumour growth igf-i group surgery control catalase growth factors tumour load peritoneum figure monolayer experiment carcinoma molecule result colon marquet rl tissue blood netherland cell adhesion molecules component mesothelial monolayer medium cavity response wound healing cell adhesion jeekel j wound colon carcinoma cells fluid tumor recurrence lavage fluid model integrin mesothelium difference expression process interaction rat mesothelial cells injury healing marquet concentration tumor cells paracrine adhesion molecules chapter jeekel lavage surface receptor traumatised muscle production table stimulation van koetsveld pm score minute culture