Campbell, M.J.

design ligand nucleus receptor figure membrane concentration import importin model protein transport response network system transcriptional response plasma membrane cytoplasm export molecule transcriptional 2010 embo macmillan publishers binding cargo plasma design principles signal ratio diffusion biology principle rangtp parameter diffusion coef ficient figure 2 g design 6 figure 2 core-nr aspect function localization exportin figure 2 b transcription kolodkin addition control ficient cytoplasmic cytosol systems biology 2010 publisher macmillan hormone pathway value glucocorticoid number reaction activity table study liganded importin-a mechanism process network designs parameter values fraction nucleocytoplasmic topology activation design 2 complexity figure 1 path j transduction 0.005 nm glucocorticoid receptor