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nf 1+/à mice simvastatin group gaba release neuron children baseline placebo synapsin acamkii phosphorylation figure 12 weeks result score release treatment control trial training neuro wt mice mipsc effect study synapsin i phosphorylation synapsin i frequency measure analysis outcome neurofibromatosis type 1 mutant 12.5 mm kcl level outcome measures neurofibromatosi deletion number mipsc frequency neuro fibromin fibromin morris water maze performance quadrant plasticity synaptic nf 1 gene increase signi hippocampal value nf 1dlx placebo groups placebo group simvastatin group inhibition nf 1 mice water presynaptic picrotoxin mouse model memory conditioning patient erasmus mc signi ficantly augmentation acamkii-t kushner 1acamkii ± sem object assembly test acamkii-ko mice object vesicle assembly target quadrant acamkii-ko fi ndings
3 Most Recent Publications
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Neurofibromin Regulation of ERK Signaling Modulates GABA Release and Learning
(Article)
Cui, Y. Costa, R.M. Murphy, G.G. Elgersma, Y. Zhu, Y. Gutmann, D.H. Parada, L.F. Mody, I. Silva, A.J. |
2008-10-31
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Effect of simvastatin on cognitive functioning in children with neurofibromatosis type 1: A randomized controlled trial
(Article)
Krab, L.C. Goede-Bolder, A. de Silva, A.J. Zeeuw, C.I. de Moll, H.A. Elgersma, Y. Aarsen, F.K. Pluijm, S. Bouman, M.J. Geest, J.N. van der Leguin, M. Catsman, C. Arts, W.F.M. Kushner, S.A. |
2008-07-16
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Kinase activity is not required for αCaMKII-dependent presynaptic plasticity at CA3-CA1 synapses
(Article)
Hojjati, M.R. Woerden, G.M. van Tyler, W.J. Giese, K.P. Silva, A.J. Pozzo-Miller, L. Elgersma, Y. |
2007-09-01
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