Nichols, W.C.

disease 1441c parkinson carrier mutation neurology substitution patient lrrk 2 parkinsonism mutation carriers parkinson disease haplotype family www.neurology.org study feature kinase department pathology figure symptom university ϯ sd age lrrk 2 mutations parkinson disease k onset information .4321c part 2 phase incidence population guest institute article downloaded genet domain disorder analysis lrrk 2 protein penetrance frequency lrrk 2 gene dopaminergic cell loss table range asymmetry cause research disord protein kinase 2 10.1212/01. wnl .0000304044.22253.03 p.r 1441c mutation age 50 years 20 families founder genetic hospital estimate medicine residue activity leucine-rich gtpase gametic phase levodopa skipper l response singapore wszolek farrer mj risk factor evidence spectrum late-onset control nucleotide polymorphisms