Aardweg, J.G. van den

airway muscle asthma inspiration patient muscle bundles subject resistance expression protein methacholine respir biopsy airway hyperresponsiveness study inspiration –induced bronchodilation bundle breath effect desmin signi ficantly signi muscle cells bronchodilation hyperresponsivenes physiol relationship type iii collagen contractile expiratory resistance challenge control subjects extracellular matrix proteins –induced response airway responses matrix number muscle area change lamina propria extracellular a-sm-actin figure control reduction function lung function pc 20 methacholine result inhalation fev 1 bronchodilatory effect elastin fi bronectin expiratory calponin section disease mast cells extracellular matrix flammatory mch inhalation myosin cd 4ϩ lymphocytes group flammatory cell counts flammation department increase density obstruction oscillation technique collagen ficantly difference breathing bronectin bronchodilatory flammatory cells