Yoshimura, A.

activation receptor pathway protein jak-stat kinase blood jak-stat pathway tyrosine j biol chem factor response leukemia cytokine mol cell biol hematopoietic stat 5 interferon embo j constitutive activation g-csf domain stat 3 constitutive interleukin stat 3 activation granulocyte colony-stimulating factor patient signal function number myeloid jak 2 mutation stat 5 activation family expression study proliferation knockout phosphorylation stat activation science stat 1 addition growth development colony-stimulating disease transcription erythropoietin activity hematopoietic cells myeloid leukemia member transcriptional granulocyte j exp med nature hematopoiesi touw ip binding transformation phenotype neutropenia example lymphoid regulation table phosphatase dominant-negative t cells mechanism j immunol jak 1 cytokine receptor superfamily result cis family members jove r bcr-abl