Silva, H.T.

patient study group transplantation drug monitoring exposure treatment concentration fixed-dose month time points hoffmann-la roche ltd mofetil mycophenolate monitoring treatment failure transplant value cyclosporine rejection mpa exposure mycophenolic tacrolimu mycophenolate mofetil event point difference relationship mycophenolic acid transplant recipients mpa-auc incidence concentration –time curve target mycophenolate mofetil therapy therapy analysis pharmacokinetic failure mpa auc concentration-controlled group dose adjustments center department gelder fixed-dose group outcome mmf dose adult fixed-dose groups roche mycophenolic acid exposure university adjustment hoffmann-la efficacy table randomized number recipient population van gelder day 3 proportion kidney target mpa exposure mpa concentrations donor grant treatment groups endpoint regimen 48 hr research grants trial nephrology perprotocol population research result calcineurin inhibitor