Pugnale, P.

patient plasma kinetic treatment hcv rna hepatitis c virus hepatitis replication group therapy response virus decay hcv replication hepatitis c ribavirin control group decline blood liver study sample quanti hepatology / journal fi rst phase hcv rna levels hcv rna kinetics quanti fication hcv rna decline model fication analysis 6 weeks control 74 patients virological response detection hcv rna decay switzerland cobas amplicortm hcv hepatitis c patients peg-ifn-a 2a compartment peg-ifn-a virological interferon time points pugnale dynamic correlation 932–938 baseline extrahepatic journal plasma samples fferent 42 weeks hcv rna replication days 1 polymerase chain reaction plasma hcv rna e ffect 20 patients treatment e ffect randomized extrahepatic replication hcv rna declines treatment response university level 1211 geneva combination 1000–1200 mg ribavirin phase delay information biphasic limit infection