Negro, F.

patient response treatment t-cell kinetic therapy hepatitis plasma hcv-speci hepatitis c virus hcv rna hepatitis c study frequency hla-a peptide analysis signi fi rst month ribavirin t-cell lines group virus decline hla-a 2 t-cell response decay non-rvr proliferative t-cell responses expansion replication figure proliferative –liver pancreas control tetramer point genotype time points value result ficant interferon correlation hcv replication rvr patients non-rvr patients control group ifn -␥ production cd 8 analysis baseline outcome cytotoxic blood signi ficance signi ficant 15- mer peptides cd 8 cells staining liver t-cell responses effect signi ficantly time point antigen tract sample quanti pancreas hepatology biliary month treatment outcome 10 days stimulation non-svr / journal fi rst phase –liver hcv rna levels