Gore, M.

patient melanoma interferon trial group survival observation treatment adjuvant stage study lymph disease interferon group number observation group eortc signi analysis cancer oncol recurrence-free survival therapy biopsy metastasis-free survival result pegylated sln biopsy event hospital randomized phase recurrence-free ficant e ffect lymph nodes adjuvant therapy impact metastase nodal margin value excision lymph node dissection recurrence signi ficant impact prognostic tumor eggermont signi ficant relapse metastasis-free center survival bene fit nodal involvement sln biopsy-positive patients death sentinel hazard ratio oncology centre bene fit tumour university table randomisation month outcome involvement toxicity vaccine analyses dissection duration metastasi thickness randomised stage iii melanoma procedure