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protein binding molecule lament complex repair rad 51 figure strand structure reaction recombination presence substrate interaction activity dsdna domain atp hydrolysis length exchange ssdna image dna molecules rad 51 fi hydrolysis filament strand exchange formation disassembly mre 11 rad 50 acids research result nucleation clip -170 nucleotide experiment nucleoprotein concentration -170 extension single-stranded dna monomer function dna substrates fl ow cell dna ends atpase position single-stranded fi lament change study recombinase damage buffer dissociation uorescence double-stranded dna resection assembly condition nuclease exo 1 region double-stranded research dna binding uorescent dna 2 atp binding control assay analysis kanaar mechanism fragment nucleotide excision repair fi lament formation
10 Most Recent Publications
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Mre11-Rad50 complex crystals suggest molecular calisthenics
(Article)
Wyman, C. Lebbink, J.H.G. Kanaar, R. |
2011-10-10
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Mechanistic insight from chaos: How RecA mediates DNA strand exchange
(Article)
Wyman, C. |
2011-08-10
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Effect of the BRCA2 CTRD domain on RAD51 filaments analyzed by an ensemble of single molecule techniques
(Article)
Holthausen, J.T. loenhout, M.T.J. van Sanchez, H. Ristic, D. Rossum-Fikkert, S.E. van Modesti, M. Dekker, C. Kanaar, R. Wyman, C. |
2011-08-01
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BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair
(Article)
Nimonkar, A.V. Genschel, J. Kinoshita, E. Polaczek, P. Campbell, J.L. Wyman, C. Modrich, P. Kowalczykowski, S.C. |
2011-02-15
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Visualizing RAD51-mediated joint molecules: Implications for recombination mechanism and the effect of sequence heterology
(Article)
Ristic, D. Kanaar, R. Wyman, C. |
2011-01-17
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Regulation of DNA strand exchange in homologous recombination
(Article)
Holthausen, J.T. Wyman, C. Kanaar, R. |
2010-12-10
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Molecular recognition of DNA-protein complexes: A straightforward method combining scanning force and fluorescence microscopy
(Article)
Sanchez, H. Kanaar, R. Wyman, C. |
2010-06-01
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Dynamics of RecA filaments on single-stranded DNA
(Article)
loenhout, M.T.J. van Heijden, T. van der Kanaar, R. Wyman, C. Dekker, C. |
2009-07-30
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RAD50 and NBS1 form a stable complex functional in DNA binding and tethering
(Article)
Linden, E. van der Sanchez, H. Kinoshita, E. Kanaar, R. Wyman, C. |
2009-04-02
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Inter-subunit interactions that coordinate Rad51's activities
(Article)
Grigorescu, A.A. Vissers, J.H.A. Ristic, D. Pigli, Y.Z. Lynch, T.W. Wyman, C. Rice, P.A. |
2009-02-12
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