Peng, B.

smoking imatinib patient grade pharmacokinetic cancer cyp 1a smoker effect study nonsmokers cyp 3a group exposure progression survival sarcoma clearance research smoking status bone sarcoma group treatment analysis metabolism pharmacol imatinib mesylate interaction article 45 patients tobacco association enzyme imatinib pharmacokinetics gist patients fatigue status efficacy result concentration toxicitie toxicity anemia cigarette american stromal cl /f outcome population cigarette smoking imatinib exposure cancer research stromal tumors peng b pharmacokinetic variables european tissue sample december smoke tumor downloaded table glycoprotein plasma copyright model www.aacrjournals.org phase pharmacokinetic data wbc counts mesylate department stromal tumours tobacco smoking influence nonlinear mixed-effect modeling distribution cyp 2d aacr publications department retrospective