Noordzij, J.G.

patient mutation protein b-cell recombination xla patients analysis rearrangement expression artemi deficiency differentiation precursor b-cell compartment blood precursor disease children table defect level activity syndrome figure van dongen jjm result arrest recombination activity bm samples immunodeficiency scid patients agammaglobulinemia receptor x-linked lymphocytes number sample compartment cytometric leukemia infection absence rag genes x-linked agammaglobulinemia b-lymphocyte flow cytometric analysis chapter kinase stage precursor b cells dongen bone marrow deletion detection domain splice control university b-cell differentiation arrest rotterdam phenotype composition marrow chain product immunol immunoglobulin btk gene diagnosis t-lymphocyte study omenn splice site mutations codon t-cell family differentiation arrest rag 1 protein omenn syndrome immunophenotyping development