Bouwmeester, J.

morphine surgery neonate group infant children concentration postoperative plasma study age groups plasma concentrations patient effect clearance score stress infusion response period metabolite postoperative pain ventilation stress responses difference analgesia comfort scale chapter month pharmacokinetic morphine requirements table requirement dosage 7 days pain management treatment ratio value postoperative analgesia morphine administration management result metabolism 3 years adult comfort scale range morphine infusion assessment morphine metabolism age group loading dose administration factor volume maturation model morphine plasma concentrations randomized baseline anand serum change m 6g ratio distribution parameter analysis morphine infusions formation behavioural trial paediatric pain scores nespeca mk pain assessment blood weight birth