Zwet, A.A. van

pylori strain metronidazole resistance helicobacter pylori helicobacter metronidazole resistance hardenberg strain amoxicillin pbp 1a amoxicillin resistance hardenberg protein condition antimicrob transformant chemother transformation mutation sequence antibiotic cell viability result agent substitution experiment gerrit table transformation experiments fragment microaerophilic microbiol incubation ser 4143arg substitution oxygen amxr hardenberg strain protein synthesis synthesis strain 1061 microaerophilic conditions /liter amxr colonies agents chemother pylori strains mtzr h oxygen conditions study pathogen helicobacter pylori amxr 1061 transformants lactam antibiotics agar dilution edward chloramphenicol penicillin-binding reversibility analysis effect acid substitutions c.f.u amxr transformants netherland reduction viability culture plate 4143arg cell wall synthesis 0.016 37 8 c lactam 1.0 mg /liter 16 metronidazole ml e-test .256 increase pylori strain 1061 product frxa gene pcr fragments rdxa gene