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monocyte mouse culture precursor er-mp nod mice dendritic expression macrophage myeloid diabetes immunol population blood dendritic cells t cells development study figure subset pancreas number nod mouse analysis spleen maturation gata 1 c 57bl mice marrow gm-csf c 57bl differentiation function chapter control level nod cultures factor stage marker progenitors lineage capacity cd 11c cells strain myeloid dc lip-cl 2mdp phenotype ly -6chigh monocytes class molecule ly -6clow monocytes islet cd 11c response 2002. system receptor antibody ly -6c depletion subpopulation leenen experiment lymphoid insuliti defect antigen blood monocytes mouse bone marrow 2003. -6chigh activation phagocytes wnt 3a inflammation treatment lymphocytes point dc precursors