Marsh, S.

patient irinotecan variant cancer pharmacokinetic allele genotype population polymorphism study transporter frequency -38 docetaxel haplotype sn -38 research database paclitaxel clearance analysis variation ugt 1a mutation number cyp 3a table group disease university sn -38g effect project cancer res laboratory plasma protein diarrhea activity genome abcc 2 genetic transport individual oatp 1b 2008. caucasian pharmacogenetic information sequence genomic slco 1b ratio metabolite phenotype health metabolism result association parameter cyp 3a allele medicine toxicity treatment effort concentration blood genet value sparreboom expression standard signi country irinotecan disposition pharmacokinetic parameters presence slco 1b gene european variability