Jacobs, R.J.

cancer hct 116 cells lovastatin statin promoter crc cells bmp 2 promoter bmp 2 treatment expression methylation methylated differentiation 2 mm lovastatin colorectal cancer effect colorectal bmp 2 expression colon study control pathway protein bmp pathway analysis marker concentration region xenograft level lovastatin treatment patient cell lines demethylation activity phenotype agent netherland 5- fu unmethylated tumour island gut.bmj.com gastroenterology hypermethylation xenograft mouse model dna methylation hct 116 xenografts colon cancer cells suppressor dnmt activity inhibitor november downloaded group.bmj.com assay cancer therapy model simvastatin 1553. 5 days result therapy promoter hypermethylation bmp 2 methylation villin unmethylated cpg sites crc cell lines stemnes transcription pcr analysis mutation demethylating goblet cell differentiation speci goblet methyltransferase leiden university statin treatment transcription dnmt inhibitors