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Brouwer, A.
(Abraham Brouwer)
sult 1e e 2 sulfation sulfation phah-oh inhibition library erasmus mc sulfotransferase estrogen liver hydroxylated ic 50 values effect compound value sult 1a result estrogen sulfotransferase liver cytosol metabolite falany erasmu cytosolic inhibitor 30- min incubation hydroxy substrate structure reaction conditions hydroxyl group table pcdf-oh falany cn hormone cancer downloaded library endocrinol enzyme pcdd-oh hydroxylated metabolites concentration protein sulfated group cytosol analysis metab 0.1 polychlorinated experiment kester estrogenic toxicol thyroid hplc analysis estrogenic effects reaction november health sulfated products chlorine substituents activity sult 1e inhibition product visser sult 1e activity study hydroxylated phah metabolites method condition breast cancer risk substituent cytosolic sulfotransferases hydroxyl core structure km value tissue hydroxylated phahs incubation chem biol
2 Most Recent Publications
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Potent inhibition of estrogen sulfotransferase by hydroxylated metabolites of polyhalogenated aromatic hydrocarbons reveals alternative mechanism for estrogenic activity of endocrine disrupters
(Article)
Kester, M.H.A. Visser, T.J. Brouwer, A. Bulduk, S. Toor, H. van Tibboel, D. Meinl, W. Glatt, H. Falany, C.N. Coughtrie, M.W. Schuur, A.G. |
2002-01-01
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Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: a novel pathway explaining the estrogenic activity of PCBs
(Article)
Kester, M.H.A. Bergman, A. Falany, C.N. Coughtrie, M.W. Kuiper, G.G.J.M. Safe, S.H. Visser, T.J. Brouwer, A. Schuur, A.G. Bulduk, S. Tibboel, D. Meinl, W. Glatt, H. |
2000-01-01
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