Boonen, A.

patient treatment arthritis health model rheumatology strategy cost-effectiveness dmard disease-modifying antirheumatic drugs disease response practice disease activity combination treatment strategies effectiveness recommendation journal modeling eular health states course review severens jl biologic nonbiologic non-commercial use health technol modeling theory evaluation severen decision event activity issue acr response eular response attribute account management antirheumatic consideration measure disease-modifying jobanputra p bansback n dmard-naive patients literature breedveld fc eular recommendations landewe r rheumatologist step-down combination rheumatol event simulation treatment decisions american college rheum boonen simulation study change scott dl state british society disease duration level patient attributes choice literature search barton p first-line treatment validation mortality risk 7. reimbursement step-up combination treatment rheumatology biologics registry practice annelies boonen non-commercial