Jurgensen, J.O.L.

level acromegaly effect patient growth insulin journal endocrinology hormone treatment igf 1 igf 1 levels serum action kopchick jj growth hormone hepatic activity tissue metabolism la-smsa disease activity extra-hepatic acromegaly european journal extra-hepatic study production portal insulin levels disease diabetes gh actions kopchick somatostatin subject european antagonist therapy glucose type 2 diabetes kidney portal chen wy acromegalic liver gh levels analog factor pegvisomant fasting secretion receptor result gh –igf axis increase signi striker lj moller jorgensen body composition octreotide herder ww striker jorgensen jo acromegalic patients type 2 ef ficacy sensitivity novel biomarkers insulin-like combination therapy vance ml striker ge protein control glomerulosclerosi speci combination la-smsa-treated acromegalic subjects gh activity scarlett ja