Smorenburg, C.H.

patient cancer paclitaxel study breast metastatic breast cancer docetaxel phase combination metastatic capecitabine oncol gemcitabine pharmacokinetic toxicity treatment breast cancer chapter agent phase i study response chemotherapy infusion cycle tumor schedule taxane clearance methotrexate level administration phase ii study 5- fu disease trial therapy grade table 1 3 h result plasma dose level effect regimen group breast cancer patients anthracycline efficacy skin metastases activity suppl analysis metastase verweij j cytotoxic exposure blood response rate miltefosine evaluable interaction month neutropenia value response rates cremophor el 5- fluorouracil cremophor concentration sequence metastatic disease range verweij phase ii trial 1 1 h dosing rotterdam function fluorouracil cell cycle