Drost, J.

brd 7 expression figure target bj /et cells pathway cancer tumour transcription p 53 pathway promoter cluster protein enhancer ep 53br mirna senescence activity control chapter mir -17-92 cluster 53-dependent suppressor growth transcriptional region transformation acetylation tumours binding target genes oncogene response activation brd 7 expression level histone regulation transcriptional cofactor information induction mcf 7 cells component knockdown vector chromatin nature experiment assay presence enhancer activity -17-92 cycle function arrest analysis 4- oht domain factor wild-type result stress breast suppression interaction agami graphs show p 21 promoter effect p 53kd oncogenic cofactor sirna antibody tumor oncogene-induced senescence brd 7kd p 53-dependent manner oncogene-induced 53.