Dent, T.H.S.

model prediction risk prediction models disease health risk prediction model cambridge university professor dementia population risk factors heart assessment factor evaluation genomic heart disease framework practice cancer study research performance type 2 diabetes risk prediction issue intervention context result approach implementation calibration phg foundation discrimination benefit treatment risk models prevention example validity development sample metric future criteria table foundation utility department outcome screening question epidemiology validation biomarker cost-effectiveness purpose cohort value novel hingorani ad breast cancer institute cooper ja medicine people disease risk models body mass index breast acce framework • risk models risk prediction studies threshold london diabetes effect decision-making information impairment