Corver, W.E.

patient cancer colorectal colorectal cancer tumour mutation syndrome cowden tumours fraction patient 1 patient 2 cowden syndrome pten expression expression tumour cells analysis cowden syndrome patients colorectal tumours tissue pten mutation carriers pi 3k carcinogenesi pathway study germline germline pten mutations fi brotic stroma polyps aneuploid colon chromosomal loss section colorectal tumour department stromal adenocarcinoma keratin-positive carrier genet report family examination colorectal carcinogenesis fi ndings pten protein expression case report evidence germline mutations microsatellite paraf fin tissues polymerase chain reaction vimentin-positive stromal cells netherland scaphoid head shape colorectal cancers family history tumor onset colorectal cancer result pi 3k pathway kersseboom erasmus university ter haar nt near-diploid rotterdam allele pten loss disease carcinoma hamartoma antibody survival level staining review model pik 3ca mlpa analysis incidence