Pico, I.

b-cell memory b cells patient b cells memory cvid patients pattern subset control ficiency number proliferation defect b-cell subsets zone –like blood immunode –like figure b-cell patterns erasmus mc 5 b-cell patterns immunode ficiency group replication b-cell proliferation center reduction immunol division range b-cell compartment history age-matched controls fication identi erasmu study cell divisions replication history analysis center defect identi fied compartment 21lowcd result decrease level background signi disease classi b-cell pattern 1 complication signi ficantly 21low abnormality development frequency 2012. library cytometric assay immunopathological backgrounds cvid blood december shm levels b-cell development volume identi fication precursor age-matched pathophysiologic backgrounds precursor b-cell compartment recombination 3 age groups fl ow cytometric b-cell pattern 2 addition immunode ficiency blood