Hoekstra, R.

patient study cancer tumor level plasma phase treatment disorder inhibitor abt -510 activity pharmacokinetic -510 agent biopterin concentration pki 166 effect toxicity neopterin chapter cycle phase i study oncol cisplatin metalloproteinase affective result matrix trial depression growth disease combination therapy group tryptophan marimastat table chemotherapy bipolar response inhibition administration model control affective disorders paclitaxel grade analysis 2 weeks number ratio light therapy infusion sample psychiatry oxide nitric regimen tyrosine 4 weeks tetrahydrobiopterin nitric oxide change phase i factor urine target phase i studies increase bms -214662 angiogenesi parameter marker matrix metalloproteinase inhibitor carcinoma serum carboplatin