Wiltgen, M.

study matter lesions lesion matter notch mutation notch 3 gene stroke cadasil disease nucleotide polymorphisms vessel disease cohort institute polymorphism notch 3 nucleotide individual brain schmidt non-synonymou region vessel effect participant health austrian prevention health study protein domain allele hypertension heart rotterdam change presence epidermal growth factor-like sequence hypertensive analyses nding association structure research framingham heart study subject promoter hyperintensity signi lacune untranslated region blood function table subcortical lacunar lesions number nucleotide polymorphism database matter lesion volume university identi fication number model fi ndings 3384–3397 01-hc homology modelling age-related carrier downloaded progression fluent consortium volume framingham linkage disequilibrium notch domain v 1952m centre european descent subcortical