Bolhuis, R.L.H.

(Reinder Bolhuis)

lymphocytes target patient cancer t lymphocytes donor target cells peptide effect tumour t cells fraction cytotoxicity activity tumor response cytotoxic lymphocyte receptor table t-cell transduction level antigen number -12 assay result antibody effector study serum ea-rfc production melanoma immunol culture virus blood medium scfvg surface 37° c therapy cytolytic hla-a transduced clone control transfer experiment activation tumour cells chain expression tumours protocol nk-cell cmv disease cancer res specificity cytokine chapter scfvg 250 ch gene transduction ratio il -12 speci effector cells cycle disease rhuil cytotoxic effects range 37° transductant percentage figure bladder injection

8 Most Recent Publications

T cell re-targeting to EBV antigens following TCR gene transfer: CD28-containing receptors mediate enhanced antigen-specific IFNgamma production (Article) Schaft, N. Lankiewicz, B. Bolhuis, R.L.H. Willemsen, R.A. Debets, J.E.M.A. Drexhage, H.A. Berrevoets, C.A. Moss, D.J. Levitsky, V. Bonneville, M. Lee, S.P. McMichael, A.J. Gratama, J-W.	2006-04-01
T cell retargeting with MHC class I-restricted antibodies: the CD28 costimulatory domain enhances antigen-specific cytotoxicity and cytokine production (Article) Willemsen, R.A. Ronteltap, C. Chames, P. Debets, J.E.M.A. Bolhuis, R.L.H.	2005-01-01
Repeated administrations of interleukin (IL)-12 are associated with persistently elevated plasma levels of IL-10 and declining IFN-gamma, tumor necrosis factor-alpha, IL-6, and IL-8 responses (Article) Portielje, J.E. Lamers, C.H.J. Kruit, W.H.J. Sparreboom, A. Bolhuis, R.L.H. Stoter, G. Huber, C. Gratama, J-W.	2003-01-01
Peptide fine specificity of anti-glycoprotein 100 CTL is preserved following transfer of engineered TCR alpha beta genes into primary human T lymphocytes (Article) Schaft, N. Willemsen, R.A. Vries, J. de Lankiewicz, B. Essers, B.W. Gratama, J-W. Figdor, C.G. Bolhuis, R.L.H.	2003-01-01
Protocol for gene transduction and expansion of human T lymphocytes for clinical immunogene therapy of cancer (Article) Lamers, C.H.J. Willemsen, R.A. Luider, B.A. Debets, J.E.M.A. Bolhuis, R.L.H.	2002-07-01
Tetramer-based quantification of cytomegalovirus (CMV)-specific CD8+ T lymphocytes in T-cell-depleted stem cell grafts and after transplantation may identify patients at risk for progressive CMV infection (Article) Gratama, J-W. Esser, J.W.J. van Lamers, C.H.J. Tournay, C. Löwenberg, B. Bolhuis, R.L.H. Cornelissen, J.J.	2001-01-01
Local but no systemic immunomodulation by intraperitoneal treatment of advanced ovarian cancer with autologous T lymphocytes re-targeted by a bi-specific monoclonal antibody (Article) Lamers, C.H.J. Bolhuis, R.L.H. Warnaar, S.O. Stoter, G. Gratama, J-W.	1997-10-01
Cell-mediated immunity to carcinoma of the urinary bladder : specificity of the reaction and the nature of the effector cells (Doctoral Thesis) Bolhuis, R.L.H.	1977-12-21

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