Laarhoven, H.W.M. van

cancer breast tamoxifen patient c-h 2ax tumor cyp 2c 53 bp 1 breast cancer patients allele genotype study cyp 2c allele disease expression cohort cyp 2d treatment adjuvant breast cancer c-h 2ax expression cyp 2c carriers damage staining disease progression tamoxifen therapy effect group cyp 2c genotype carrier status association receptor telomere cyp 2c activity breast cancer res therapy factor result tamoxifen metabolism cyp 2c patients outcome cyp 2d genotype c-h 2ax foci genomic instability genomic tamoxifen treatment metabolite variant netherland metabolism number repair oncol . clin prognostic pathway figure breast tumor specimens prognostic value month order activity research endoxifen progression oncology 4- oh-tamoxifen contact bonner wm dna damage staining intensities breast cancers radiotherapy future @futuremedicine article -4-oh radiother reprint